2jmh

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{{STRUCTURE_2jmh| PDB=2jmh | SCENE= }}
{{STRUCTURE_2jmh| PDB=2jmh | SCENE= }}
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'''NMR solution structure of Blo t 5, a major mite allergen from Blomia tropicalis'''
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===NMR solution structure of Blo t 5, a major mite allergen from Blomia tropicalis===
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==Overview==
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Blo t 5 is the major allergen from Blomia tropicalis mites and shows strong IgE reactivity with up to 90% of asthmatic and rhinitis patients' sera. The NMR solution structure of Blo t 5 comprises three long alpha helices, forming a coiled-coil, triple-helical bundle with a left-handed twist. TROSY-NMR experiments were used to study Blo t 5 interaction with the Fab' of a specific monoclonal antibody, mAb 4A7. The mAb epitope comprises two closely spaced surfaces, I and II, connected by a sharp turn and bearing critical residues Asn46 and Lys47 on one surface, and Lys54 and Arg57 on the other. This discontinuous epitope overlaps with the human IgE epitope(s) of Blo t 5. Epitope surface II is further predicted to undergo conformational exchange in the millisecond to microsecond range. The results presented are critical for the design of a hypoallergenic Blo t 5 for efficacious immunotherapy of allergic diseases.
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{{ABSTRACT_PUBMED_18184590}}
==About this Structure==
==About this Structure==
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2JMH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Blomia_tropicalis Blomia tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMH OCA].
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2JMH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Blomia_tropicalis Blomia tropicalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMH OCA].
==Reference==
==Reference==
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[[Category: Dust mite]]
[[Category: Dust mite]]
[[Category: Group 5]]
[[Category: Group 5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:01:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:35:44 2008''

Revision as of 13:35, 28 July 2008

Image:2jmh.png

Template:STRUCTURE 2jmh

NMR solution structure of Blo t 5, a major mite allergen from Blomia tropicalis

Template:ABSTRACT PUBMED 18184590

About this Structure

2JMH is a Single protein structure of sequence from Blomia tropicalis. Full experimental information is available from OCA.

Reference

Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: an NMR study on Blomia tropicalis major allergen., Naik MT, Chang CF, Kuo IC, Kung CC, Yi FC, Chua KY, Huang TH, Structure. 2008 Jan;16(1):125-36. PMID:18184590

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