2jmp

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{{STRUCTURE_2jmp| PDB=2jmp | SCENE= }}
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'''Structure for the N-terminus of chromosomal replication initiation protein dnaA from M. genitalium'''
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===Structure for the N-terminus of chromosomal replication initiation protein dnaA from M. genitalium===
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==Overview==
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DnaA is an essential component in the initiation of bacterial chromosomal replication. DnaA binds to a series of 9 base pair repeats leading to oligomerization, recruitment of the DnaBC helicase, and the assembly of the replication fork machinery. The structure of the N-terminal domain (residues 1-100) of DnaA from Mycoplasma genitalium was determined by NMR spectroscopy. The backbone r.m.s.d. for the first 86 residues was 0.6 +/- 0.2 A based on 742 NOE, 50 hydrogen bond, 46 backbone angle, and 88 residual dipolar coupling restraints. Ultracentrifugation studies revealed that the domain is monomeric in solution. Features on the protein surface include a hydrophobic cleft flanked by several negative residues on one side, and positive residues on the other. A negatively charged ridge is present on the opposite face of the protein. These surfaces may be important sites of interaction with other proteins involved in the replication process. Together, the structure and NMR assignments should facilitate the design of new experiments to probe the protein-protein interactions essential for the initiation of DNA replication.
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{{ABSTRACT_PUBMED_17680349}}
==About this Structure==
==About this Structure==
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2JMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMP OCA].
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2JMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMP OCA].
==Reference==
==Reference==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:02:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:55:38 2008''

Revision as of 05:55, 28 July 2008

Image:2jmp.png

Template:STRUCTURE 2jmp

Structure for the N-terminus of chromosomal replication initiation protein dnaA from M. genitalium

Template:ABSTRACT PUBMED 17680349

About this Structure

2JMP is a Single protein structure of sequence from Mycoplasma genitalium. Full experimental information is available from OCA.

Reference

NMR structure of the N-terminal domain of the replication initiator protein DnaA., Lowery TJ, Pelton JG, Chandonia JM, Kim R, Yokota H, Wemmer DE, J Struct Funct Genomics. 2007 Mar;8(1):11-7. Epub 2007 Aug 7. PMID:17680349

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