2jnf

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[[Image:2jnf.jpg|left|200px]]
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{{STRUCTURE_2jnf| PDB=2jnf | SCENE= }}
{{STRUCTURE_2jnf| PDB=2jnf | SCENE= }}
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'''Solution structure of fly troponin C, isoform F1'''
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===Solution structure of fly troponin C, isoform F1===
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==Overview==
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To gain a molecular description of how muscles can be activated by mechanical stretch, we have solved the structure of the calcium-loaded F1 isoform of troponin C (TnC) from Lethocerus and characterized its interactions with troponin I (TnI). We show that the presence of only one calcium cation in the fourth EF hand motif is sufficient to induce an open conformation in the C-terminal lobe of F1 TnC, in contrast with what is observed in vertebrate muscle. This lobe interacts in a calcium-independent way both with the N terminus of TnI and, with lower affinity, with a region of TnI equivalent to the switch and inhibitory peptides of vertebrate muscles. Using both synthetic peptides and recombinant proteins, we show that the N lobe of F1 TnC is not engaged in interactions with TnI, excluding a regulatory role of this domain. These findings provide insights into mechanically stimulated muscle contraction.
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The line below this paragraph, {{ABSTRACT_PUBMED_17637342}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17637342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17637342}}
==About this Structure==
==About this Structure==
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2JNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNF OCA].
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2JNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNF OCA].
==Reference==
==Reference==
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[[Category: Stretch activated muscle contraction]]
[[Category: Stretch activated muscle contraction]]
[[Category: Troponin c]]
[[Category: Troponin c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:04:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:50:37 2008''

Revision as of 11:50, 28 July 2008

Image:2jnf.png

Template:STRUCTURE 2jnf

Solution structure of fly troponin C, isoform F1

Template:ABSTRACT PUBMED 17637342

About this Structure

2JNF is a Single protein structure of sequence from Thermomicrobium roseum. Full experimental information is available from OCA.

Reference

The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles., De Nicola G, Burkart C, Qiu F, Agianian B, Labeit S, Martin S, Bullard B, Pastore A, Structure. 2007 Jul;15(7):813-24. PMID:17637342

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