2jnr

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[[Image:2jnr.jpg|left|200px]]
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{{STRUCTURE_2jnr| PDB=2jnr | SCENE= }}
{{STRUCTURE_2jnr| PDB=2jnr | SCENE= }}
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'''Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide'''
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===Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide===
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==Overview==
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A variety of molecules in human blood have been implicated in the inhibition of HIV-1. However, it remained elusive which circulating natural compounds are most effective in controlling viral replication in vivo. To identify natural HIV-1 inhibitors we screened a comprehensive peptide library generated from human hemofiltrate. The most potent fraction contained a 20-residue peptide, designated VIRUS-INHIBITORY PEPTIDE (VIRIP), corresponding to the C-proximal region of alpha1-antitrypsin, the most abundant circulating serine protease inhibitor. We found that VIRIP inhibits a wide variety of HIV-1 strains including those resistant to current antiretroviral drugs. Further analysis demonstrated that VIRIP blocks HIV-1 entry by interacting with the gp41 fusion peptide and showed that a few amino acid changes increase its antiretroviral potency by two orders of magnitude. Thus, as a highly specific natural inhibitor of the HIV-1 gp41 fusion peptide, VIRIP may lead to the development of another class of antiretroviral drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17448989 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17448989}}
==About this Structure==
==About this Structure==
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2JNR is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA].
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2JNR is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA].
==Reference==
==Reference==
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[[Category: Wilhelm, D.]]
[[Category: Wilhelm, D.]]
[[Category: Peptide complex]]
[[Category: Peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:04:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:01:12 2008''

Revision as of 05:01, 28 July 2008

Image:2jnr.png

Template:STRUCTURE 2jnr

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

Template:ABSTRACT PUBMED 17448989

About this Structure

2JNR is a Single protein structure. Full experimental information is available from OCA.

Reference

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide., Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F, Cell. 2007 Apr 20;129(2):263-75. PMID:17448989

Page seeded by OCA on Mon Jul 28 08:01:12 2008

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