2jph

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{{STRUCTURE_2jph| PDB=2jph | SCENE= }}
{{STRUCTURE_2jph| PDB=2jph | SCENE= }}
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'''NMR solution structure of the Rho GTPase binding domain of human plexin-b1'''
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===NMR solution structure of the Rho GTPase binding domain of human plexin-b1===
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==Overview==
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The plexin family of transmembrane receptors are important for axon guidance, angiogenesis, but also in cancer. Recently, plexin-B1 somatic missense mutations were found in both primary tumors and metastases of breast and prostate cancers, with several mutations mapping to the Rho GTPase binding domain (RBD) in the cytoplasmic region of the receptor. Here we present the NMR solution structure of this domain, confirming that the protein has both a ubiquitin-like fold and surface features. Oncogenic mutations T1795A and T1802A are located in a loop region, perturb the average structure locally, and have no effect on Rho GTPase binding affinity. Mutations L1815F and L1815P are located at the Rho GTPase binding site and are associated with a complete loss of binding for Rac1 and Rnd1. Both are found to disturb the conformation of the beta3-beta4 sheet and the orientation of surrounding side chains. Our study suggests that the oncogenic behavior of the mutants can be rationalized with reference to the structure of the RBD of plexin-B1.
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{{ABSTRACT_PUBMED_18275816}}
==About this Structure==
==About this Structure==
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2JPH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPH OCA].
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2JPH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPH OCA].
==Reference==
==Reference==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Ubiquitin fold]]
[[Category: Ubiquitin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:09:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 5 16:24:19 2008''

Revision as of 13:24, 5 July 2008

Image:2jph.png

Template:STRUCTURE 2jph

NMR solution structure of the Rho GTPase binding domain of human plexin-b1

Template:ABSTRACT PUBMED 18275816

About this Structure

2JPH is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain., Tong Y, Hota PK, Hamaneh MB, Buck M, Structure. 2008 Feb;16(2):246-58. PMID:18275816

Page seeded by OCA on Sat Jul 5 16:24:19 2008

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