2jpz

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[[Image:2jpz.gif|left|200px]]
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{{STRUCTURE_2jpz| PDB=2jpz | SCENE= }}
{{STRUCTURE_2jpz| PDB=2jpz | SCENE= }}
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'''Structure of the hybrid-2 type intramolecular human telomeric G-quadruplex'''
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===Structure of the hybrid-2 type intramolecular human telomeric G-quadruplex===
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==Overview==
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Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomerase, thus the intramolecular telomeric G-quadruplexes have been considered as an attractive anticancer target. Information of intramolecular telomeric G-quadruplex structures formed under physiological conditions is important for structure-based drug design. Here, we report the first structure of the major intramolecular G-quadruplex formed in a native, non-modified human telomeric sequence in K(+) solution. This is a hybrid-type mixed parallel/antiparallel-G-stranded G-quadruplex, one end of which is covered by a novel T:A:T triple capping structure. This structure (Hybrid-2) and the previously reported Hybrid-1 structure differ in their loop arrangements, strand orientations and capping structures. The distinct capping structures appear to be crucial for the favored formation of the specific hybrid-type intramolecular telomeric G-quadruplexes, and may provide specific binding sites for drug targeting. Our study also shows that while the hybrid-type G-quadruplexes appear to be the major conformations in K(+) solution, human telomeric sequences are always in equilibrium between Hybrid-1 and Hybrid-2 structures, which is largely determined by the 3'-flanking sequence. Furthermore, both hybrid-type G-quadruplexes suggest a straightforward means for multimer formation with effective packing in the human telomeric sequence and provide important implications for drug targeting of G-quadruplexes in human telomeres.
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The line below this paragraph, {{ABSTRACT_PUBMED_17626043}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17626043 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17626043}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPZ OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Quadruplex]]
[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:10:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:15:42 2008''

Revision as of 21:15, 27 July 2008

Image:2jpz.png

Template:STRUCTURE 2jpz

Structure of the hybrid-2 type intramolecular human telomeric G-quadruplex

Template:ABSTRACT PUBMED 17626043

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence., Dai J, Carver M, Punchihewa C, Jones RA, Yang D, Nucleic Acids Res. 2007;35(15):4927-40. Epub 2007 Jul 10. PMID:17626043

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