2bh9
From Proteopedia
(New page: 200px<br /> <applet load="2bh9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bh9, resolution 2.50Å" /> '''X-RAY STRUCTURE OF ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BH9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.49 1.1.1.49]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BH9 OCA]]. | + | 2BH9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Glucose-6-phosphate_1-dehydrogenase Glucose-6-phosphate 1-dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.49 1.1.1.49]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BH9 OCA]]. |
==Reference== | ==Reference== | ||
Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase., Kotaka M, Gover S, Vandeputte-Rutten L, Au SW, Lam VM, Adams MJ, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):495-504. Epub 2005, Apr 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15858258 15858258] | Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase., Kotaka M, Gover S, Vandeputte-Rutten L, Au SW, Lam VM, Adams MJ, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):495-504. Epub 2005, Apr 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15858258 15858258] | ||
| + | [[Category: Glucose-6-phosphate 1-dehydrogenase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oxidoreductase (choh(d)-nadp)]] | [[Category: oxidoreductase (choh(d)-nadp)]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:21:49 2007'' |
Revision as of 10:17, 30 October 2007
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X-RAY STRUCTURE OF A DELETION VARIANT OF HUMAN GLUCOSE 6-PHOSPHATE DEHYDROGENASE COMPLEXED WITH STRUCTURAL AND COENZYME NADP
Overview
Human glucose-6-phosphate dehydrogenase (G6PD) is NADP(+)-dependent and, catalyses the first and rate-limiting step of the pentose phosphate shunt., Binary complexes of the human deletion mutant, DeltaG6PD, with, glucose-6-phosphate and NADP(+) have been crystallized and their, structures solved to 2.9 and 2.5 A, respectively. The structures are, compared with the previously determined structure of the Canton variant of, human G6PD (G6PD(Canton)) in which NADP(+) is bound at the structural, site. Substrate binding in DeltaG6PD is shown to be very similar to that, described previously in Leuconostoc mesenteroides G6PD. NADP(+) binding at, the coenzyme site is seen to be comparable to NADP(+) binding in L., mesenteroides G6PD, although some differences arise as a result of, sequence ... [(full description)]
About this Structure
2BH9 is a [Single protein] structure of sequence from [Homo sapiens] with NAP and GOL as [ligands]. Active as [Glucose-6-phosphate 1-dehydrogenase], with EC number [1.1.1.49]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase., Kotaka M, Gover S, Vandeputte-Rutten L, Au SW, Lam VM, Adams MJ, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):495-504. Epub 2005, Apr 20. PMID:15858258
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