2jqq

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[[Image:2jqq.jpg|left|200px]]
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[[Image:2jqq.png|left|200px]]
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{{STRUCTURE_2jqq| PDB=2jqq | SCENE= }}
{{STRUCTURE_2jqq| PDB=2jqq | SCENE= }}
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'''Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p)'''
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===Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p)===
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==Overview==
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The conserved oligomeric Golgi (COG) complex is strongly implicated in retrograde vesicular trafficking within the Golgi apparatus. Although its mechanism of action is poorly understood, it has been proposed to function by mediating the initial physical contact between transport vesicles and their membrane targets. An analogous role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex essential for trafficking to the plasma membrane. Here we report the solution structure of a large portion of yeast Cog2p, one of eight subunits composing the COG complex. The structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. This finding provides the first structural evidence that COG, like the exocyst and potentially other tethering complexes, is constructed from helical bundles. These structures may represent platforms for interaction with other trafficking proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17565980 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17565980}}
==About this Structure==
==About this Structure==
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2JQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQQ OCA].
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2JQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQQ OCA].
==Reference==
==Reference==
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[[Category: Tethering]]
[[Category: Tethering]]
[[Category: Vesicular transport]]
[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:11:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:19:14 2008''

Revision as of 06:19, 29 July 2008

Image:2jqq.png

Template:STRUCTURE 2jqq

Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p)

Template:ABSTRACT PUBMED 17565980

About this Structure

2JQQ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structural analysis of conserved oligomeric Golgi complex subunit 2., Cavanaugh LF, Chen X, Richardson BC, Ungar D, Pelczer I, Rizo J, Hughson FM, J Biol Chem. 2007 Aug 10;282(32):23418-26. Epub 2007 Jun 12. PMID:17565980

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