2jsb

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[[Image:2jsb.jpg|left|200px]]
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{{Seed}}
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[[Image:2jsb.png|left|200px]]
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{{STRUCTURE_2jsb| PDB=2jsb | SCENE= }}
{{STRUCTURE_2jsb| PDB=2jsb | SCENE= }}
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'''Solution structure of arenicin-1'''
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===Solution structure of arenicin-1===
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==Overview==
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The solution structure and the mode of action of arenicin isoform 1, an antimicrobial peptide with a unique 18-residue loop structure, from the lugworm Arenicola marina were elucidated here. Arenicin folds into a two-stranded antiparallel beta-sheet. It exhibits high antibacterial activity at 37 and 4 degrees C against Gram-negative bacteria, including polymyxin B-resistant Proteus mirabilis. Bacterial killing occurs within minutes and is accompanied by membrane permeabilization, membrane detachment and release of cytoplasm. Interaction of arenicin with reconstituted membranes that mimic the lipopolysaccharide-containing outer membrane or the phospholipid-containing plasma membrane of Gram-negative bacteria exhibited no pronounced lipid specificity. Arenicin-induced current fluctuations in planar lipid bilayers correspond to the formation of short-lived heterogeneously structured lesions. Our results strongly suggest that membrane interaction plays a pivotal role in the antibacterial activity of arenicin.
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The line below this paragraph, {{ABSTRACT_PUBMED_17935487}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17935487 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17935487}}
==About this Structure==
==About this Structure==
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2JSB is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSB OCA].
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2JSB is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSB OCA].
==Reference==
==Reference==
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[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Poreforming]]
[[Category: Poreforming]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:15:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:13:10 2008''

Revision as of 06:13, 29 July 2008

Image:2jsb.png

Template:STRUCTURE 2jsb

Solution structure of arenicin-1

Template:ABSTRACT PUBMED 17935487

About this Structure

2JSB is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure and mode of action of the antimicrobial peptide arenicin., Andra J, Jakovkin I, Grotzinger J, Hecht O, Krasnosdembskaya AD, Goldmann T, Gutsmann T, Leippe M, Biochem J. 2008 Feb 15;410(1):113-22. PMID:17935487

Page seeded by OCA on Tue Jul 29 09:13:10 2008

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