2jvu

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{{STRUCTURE_2jvu| PDB=2jvu | SCENE= }}
{{STRUCTURE_2jvu| PDB=2jvu | SCENE= }}
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'''Solution Structure of Dispersin from Enteroaggregative Escherichia coli'''
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===Solution Structure of Dispersin from Enteroaggregative Escherichia coli===
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==Overview==
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Enteroaggregative Escherichia coli (EAEC), increasingly recognized as an important cause of infant and travelers' diarrhoea, exhibits an aggregative, stacked-brick pattern of adherence to epithelial cells. Adherence is mediated by aggregative adherence fimbriae (AAFs), which are encoded on the pAA virulence plasmid. We recently described a highly prevalent pAA plasmid-borne gene, aap, which encodes a protein (nicknamed dispersin) that is secreted to the bacterial cell surface. Dispersin-null mutants display a unique hyper-aggregating phenotype, accompanied by collapse of AAF pili onto the bacterial cell surface. To study the mechanism of this effect, we solved the structure of dispersin from EAEC strain 042 using solution NMR, revealing a stable beta-sandwich with a conserved net positive surface charge of +3 to +4 among 23 dispersin alleles. Experimental data suggest that dispersin binds non-covalently to lipopolysaccharide on the surface of the bacterium. We also show that the AAF organelles contribute positive charge to the bacterial surface, suggesting that dispersin's role in fimbrial function is to overcome electrostatic attraction between AAF and the bacterial surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 17986189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17986189}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVU OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVU OCA].
==Reference==
==Reference==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:13:54 2008''

Revision as of 07:13, 28 July 2008

Image:2jvu.png

Template:STRUCTURE 2jvu

Solution Structure of Dispersin from Enteroaggregative Escherichia coli

Template:ABSTRACT PUBMED 17986189

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli., Velarde JJ, Varney KM, Inman KG, Farfan M, Dudley E, Fletcher J, Weber DJ, Nataro JP, Mol Microbiol. 2007 Dec;66(5):1123-35. Epub 2007 Nov 6. PMID:17986189

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