2jwa

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[[Image:2jwa.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2jwa| PDB=2jwa | SCENE= }}
{{STRUCTURE_2jwa| PDB=2jwa | SCENE= }}
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'''ErbB2 transmembrane segment dimer spatial structure'''
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===ErbB2 transmembrane segment dimer spatial structure===
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==Overview==
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Proper lateral dimerization of transmembrane domain of receptor tyrosine kinases is required for biochemical signal transduction across plasma membrane. Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelle was obtained by solution NMR followed by molecular dynamics relaxation in explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif T(652)X(3)S(656)X(3)G(660), providing explanation for pathogenic power of some oncogenic mutations.
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(as it appears on PubMed at http://www.pubmed.gov), where 18178548 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18178548}}
==About this Structure==
==About this Structure==
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2JWA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWA OCA].
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2JWA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWA OCA].
==Reference==
==Reference==
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[[Category: Transmembrane helix dimer]]
[[Category: Transmembrane helix dimer]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:20:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:42:14 2008''

Revision as of 12:42, 28 July 2008

Image:2jwa.png

Template:STRUCTURE 2jwa

ErbB2 transmembrane segment dimer spatial structure

Template:ABSTRACT PUBMED 18178548

About this Structure

2JWA is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state., Bocharov EV, Mineev KS, Volynsky PE, Ermolyuk YS, Tkach EN, Sobol AG, Chupin VV, Kirpichnikov MP, Efremov RG, Arseniev AS, J Biol Chem. 2008 Jan 4;. PMID:18178548

Page seeded by OCA on Mon Jul 28 15:42:14 2008

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