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2jwq

From Proteopedia

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[[Image:2jwq.jpg|left|200px]]
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{{STRUCTURE_2jwq| PDB=2jwq | SCENE= }}
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'''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study'''
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===G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study===
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==Overview==
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The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.
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(as it appears on PubMed at http://www.pubmed.gov), where 17385760 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17385760}}
==About this Structure==
==About this Structure==
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2JWQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].
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2JWQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].
==Reference==
==Reference==
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[[Category: Quinacridine]]
[[Category: Quinacridine]]
[[Category: Telomerase inhibitor]]
[[Category: Telomerase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:21:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:29:55 2008''

Revision as of 18:29, 27 July 2008

Image:2jwq.png

Template:STRUCTURE 2jwq

G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study

Template:ABSTRACT PUBMED 17385760

About this Structure

2JWQ is a Single protein structure. Full experimental information is available from OCA.

Reference

G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66. PMID:17385760

Page seeded by OCA on Sun Jul 27 21:29:55 2008

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