2jyd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2jyd.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2jyd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2jyd| PDB=2jyd | SCENE= }}
{{STRUCTURE_2jyd| PDB=2jyd | SCENE= }}
-
'''Structure of the fifth zinc finger of Myelin Transcription Factor 1'''
+
===Structure of the fifth zinc finger of Myelin Transcription Factor 1===
-
==Overview==
+
<!--
-
Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most diverse superclasses of protein structural motifs in eukaryotes. Although our understanding of the functions of several classes of these domains is relatively well developed, we know much less about the molecular mechanisms of action of many others. Myelin transcription factor 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and mammals and are found in a range of sequence contexts. MyT1, one of the early transcription factors expressed in the developing central nervous system, contains seven MyT1 ZnFs that are very highly conserved both within the protein and between species. We have used a range of biophysical techniques, including NMR spectroscopy and data-driven macromolecular docking, to investigate the structural basis for the interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18073212}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18073212 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18073212}}
==About this Structure==
==About this Structure==
-
2JYD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYD OCA].
+
2JYD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYD OCA].
==Reference==
==Reference==
Line 42: Line 46:
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:24:06 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:00:22 2008''

Revision as of 18:00, 2 July 2008

Image:2jyd.png

Template:STRUCTURE 2jyd

Structure of the fifth zinc finger of Myelin Transcription Factor 1

Template:ABSTRACT PUBMED 18073212

About this Structure

2JYD is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1., Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP, J Biol Chem. 2008 Feb 22;283(8):5158-67. Epub 2007 Dec 11. PMID:18073212

Page seeded by OCA on Wed Jul 2 21:00:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jyd"
Personal tools