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2jyp

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{{STRUCTURE_2jyp| PDB=2jyp | SCENE= }}
{{STRUCTURE_2jyp| PDB=2jyp | SCENE= }}
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'''Coordinates for lowest energy structure of Aragonite protein-7, C-terminal domain'''
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===Coordinates for lowest energy structure of Aragonite protein-7, C-terminal domain===
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==Overview==
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The RING or Really Interesting New Gene represents a family of eukaryotic sequences that bind Zn (II) ions and participate in intracellular processes involving protein-protein interaction. Although found in over 400 different proteins, very little is known regarding the structure-function properties of these domains because of the aggregation problems associated with RING sequences. To augment this data set, we report an unusual 36 AA C-terminal sequence of an extracellular matrix mollusk shell protein, AP7, that exhibits partial homology to the RING family. This Cys, His-containing sequence, termed AP7C, binds Zn (II) and other multivalent ions, but does not utilize a tetracoordinate complexation scheme for binding such as that found in Zn (II) finger polypeptides. Moreover, unlike Zn (II) finger and RING domains, this 36 AA can fold into a relatively stable structure in the absence of Zn (II). This folded structure consists of three short helical segments (A, B, and C), with segments A and B separated by a 4 AA type I beta-turn region and segments B and C separated by a 7 AA loop-like region. Interestingly, the putative RING-like region, -RRPFHECALCYSI-, experiences slow conformational exchange between two structural states in solution, most likely in response to imido ring interconversion at P8 and P21. Poisson-Boltzmann solvation calculations reveal that the AP7C molecular surface possesses a cationic region near its N-terminus, which lies adjacent to the 30 AA mineral modification domain in the AP7 protein. Given that the AP7C sequence does not influence mineralization, it is probable that this cationic pseudo-RING region is utilized by the AP7 protein for other tasks such as protein-protein interaction within the mollusk shell matrix.
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(as it appears on PubMed at http://www.pubmed.gov), where 18298090 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18298090}}
==About this Structure==
==About this Structure==
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2JYP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYP OCA].
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2JYP is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYP OCA].
==Reference==
==Reference==
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[[Category: Protein c-terminal fragment]]
[[Category: Protein c-terminal fragment]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:24:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:43:30 2008''

Revision as of 01:43, 28 July 2008

Image:2jyp.png

Template:STRUCTURE 2jyp

Coordinates for lowest energy structure of Aragonite protein-7, C-terminal domain

Template:ABSTRACT PUBMED 18298090

About this Structure

2JYP is a Single protein structure. Full experimental information is available from OCA.

Reference

Identification and Structural Characterization of an Unusual RING-Like Sequence within an Extracellular Biomineralization Protein, AP7., Collino S, Kim IW, Evans JS, Biochemistry. 2008 Mar 25;47(12):3745-55. Epub 2008 Feb 26. PMID:18298090

Page seeded by OCA on Mon Jul 28 04:43:30 2008

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