2mib

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{{STRUCTURE_2mib| PDB=2mib | SCENE= }}
{{STRUCTURE_2mib| PDB=2mib | SCENE= }}
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'''THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION'''
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===THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION===
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==Overview==
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The three-dimensional structure of recombinant murine interleukin-1 beta has been solved by X-ray crystallographic techniques to 2.8 A resolution and refined to a crystallographic R factor of 0.192. Although murine interleukin-1 beta crystallizes in the same space group as human interleukin-1 beta with almost identical unit cell dimensions, the packing of the molecules is quite different. The murine interleukin-1 beta structure was solved by molecular replacement using the refined structure of human interleukin-1 beta as trial structure, and found to be related to the human structure by a nearly perfect twofold rotation about the crystallographic y-axis and a 14 degrees rotation about the z-axis, with no translation. The folding of murine interleukin-1 beta is similar to that found for the human variant, consisting of 12 beta strands wrapped around a core of hydrophobic side chains in a tetrahedron-like fashion. Significant differences with respect to the human structure are seen at the N terminus and in 4 of the 11 loops connecting the 12 beta strands.
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(as it appears on PubMed at http://www.pubmed.gov), where 1807351 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1807351}}
==About this Structure==
==About this Structure==
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[[Category: Schmitz, A.]]
[[Category: Schmitz, A.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:33:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:06:12 2008''

Revision as of 01:06, 28 July 2008

Image:2mib.png

Template:STRUCTURE 2mib

THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1807351

About this Structure

2MIB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of murine interleukin-1 beta at 2.8 A resolution., van Oostrum J, Priestle JP, Grutter MG, Schmitz A, J Struct Biol. 1991 Oct;107(2):189-95. PMID:1807351

Page seeded by OCA on Mon Jul 28 04:06:12 2008

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