This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2nnz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2nnz.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2nnz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nnz| PDB=2nnz | SCENE= }}
{{STRUCTURE_2nnz| PDB=2nnz | SCENE= }}
-
'''Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus'''
+
===Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus===
-
==Overview==
+
<!--
-
AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17610131}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17610131 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17610131}}
==About this Structure==
==About this Structure==
-
2NNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA].
+
2NNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA].
==Reference==
==Reference==
Line 34: Line 38:
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:41:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:26:26 2008''

Revision as of 05:26, 29 July 2008

Image:2nnz.png

Template:STRUCTURE 2nnz

Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus

Template:ABSTRACT PUBMED 17610131

About this Structure

2NNZ is a Single protein structure of sequence from Archaeoglobus fulgidus. Full experimental information is available from OCA.

Reference

Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131

Page seeded by OCA on Tue Jul 29 08:26:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nnz"
Personal tools