2npl

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[[Image:2npl.gif|left|200px]]
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{{STRUCTURE_2npl| PDB=2npl | SCENE= }}
{{STRUCTURE_2npl| PDB=2npl | SCENE= }}
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'''NMR Structure of CARD d2 Domain'''
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===NMR Structure of CARD d2 Domain===
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==Overview==
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The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.
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(as it appears on PubMed at http://www.pubmed.gov), where 17322536 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17322536}}
==About this Structure==
==About this Structure==
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2NPL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].
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2NPL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].
==Reference==
==Reference==
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[[Category: Jiang, S.]]
[[Category: Jiang, S.]]
[[Category: Coxsakievirus and adenovirus receptor]]
[[Category: Coxsakievirus and adenovirus receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:44:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:00:36 2008''

Revision as of 12:00, 27 July 2008

Image:2npl.png

Template:STRUCTURE 2npl

NMR Structure of CARD d2 Domain

Template:ABSTRACT PUBMED 17322536

About this Structure

2NPL is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:17322536

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