2npp

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{{STRUCTURE_2npp| PDB=2npp | SCENE= }}
{{STRUCTURE_2npp| PDB=2npp | SCENE= }}
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'''Structure of the Protein Phosphatase 2A Holoenzyme'''
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===Structure of the Protein Phosphatase 2A Holoenzyme===
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==Overview==
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Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit. Here we report the crystal structure of the heterotrimeric PP2A holoenzyme involving the regulatory subunit B'/B56/PR61. Surprisingly, the B'/PR61 subunit has a HEAT-like (huntingtin-elongation-A subunit-TOR-like) repeat structure, similar to that of the scaffolding subunit. The regulatory B'/B56/PR61 subunit simultaneously interacts with the catalytic subunit as well as the conserved ridge of the scaffolding subunit. The carboxyterminus of the catalytic subunit recognizes a surface groove at the interface between the B'/B56/PR61 subunit and the scaffolding subunit. Compared to the scaffolding subunit in the PP2A core enzyme, formation of the holoenzyme forces the scaffolding subunit to undergo pronounced conformational rearrangements. This structure reveals significant ramifications for understanding the function and regulation of PP2A.
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(as it appears on PubMed at http://www.pubmed.gov), where 17174897 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17174897}}
==About this Structure==
==About this Structure==
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[[Category: Heat repeat]]
[[Category: Heat repeat]]
[[Category: Protein-protein complexl]]
[[Category: Protein-protein complexl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:45:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:54:20 2008''

Revision as of 23:54, 28 July 2008

Image:2npp.png

Template:STRUCTURE 2npp

Structure of the Protein Phosphatase 2A Holoenzyme

Template:ABSTRACT PUBMED 17174897

About this Structure

2NPP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the protein phosphatase 2A holoenzyme., Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y, Cell. 2006 Dec 15;127(6):1239-51. PMID:17174897

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