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2nq3

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{{STRUCTURE_2nq3| PDB=2nq3 | SCENE= }}
{{STRUCTURE_2nq3| PDB=2nq3 | SCENE= }}
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'''Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase'''
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===Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase===
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==Overview==
 
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We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach. Predicted peptide sequence and chromosomal mapping identified the cloned molecule to be the product of the human ortholog of the mouse Itch gene, which has been implicated previously in the regulation of growth and differentiation of erythroid and lymphoid cells. Transfection experiments indicate that this human ITCH protein can act as a transcriptional corepressor of p45/NF-E2. Our data provide novel insights into the functional roles of the mammalian ITCH proteins in the development of hematopoietic cell lineages.
 
==About this Structure==
==About this Structure==
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2NQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ3 OCA].
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2NQ3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQ3 OCA].
==Reference==
==Reference==
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Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2., Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK, Genomics. 2001 Apr 15;73(2):238-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11318614 11318614]
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<ref group="xtra">PMID:11318614</ref><ref group="xtra">PMID:9647693</ref><ref group="xtra">PMID:11046148</ref><ref group="xtra">PMID:12226085</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]
[[Category: Avvakumov, G V.]]
[[Category: Avvakumov, G V.]]
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[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:46:09 2008''
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Revision as of 12:30, 17 February 2009

Image:2nq3.png

Template:STRUCTURE 2nq3

Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase

About this Structure

2NQ3 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK. Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. Genomics. 2001 Apr 15;73(2):238-41. PMID:11318614 doi:10.1006/geno.2001.6512
  • Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol Cell Neurosci. 1998 Jun;11(3):149-60. PMID:9647693 doi:10.1006/mcne.1998.0677
  • Winberg G, Matskova L, Chen F, Plant P, Rotin D, Gish G, Ingham R, Ernberg I, Pawson T. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol. 2000 Nov;20(22):8526-35. PMID:11046148
  • Courbard JR, Fiore F, Adelaide J, Borg JP, Birnbaum D, Ollendorff V. Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. J Biol Chem. 2002 Nov 22;277(47):45267-75. Epub 2002 Sep 10. PMID:12226085 doi:10.1074/jbc.M206460200

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