2ns3

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[[Image:2ns3.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2ns3| PDB=2ns3 | SCENE= }}
{{STRUCTURE_2ns3| PDB=2ns3 | SCENE= }}
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'''Solution structure of ribbon BuIA'''
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===Solution structure of ribbon BuIA===
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==Overview==
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BACKGROUND: Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin. RESULTS: In the current study we show the native globular disulfide connectivity of BuIA displays multiple conformations in solution whereas the non-native ribbon isomer has a single well-defined conformation. Despite having multiple conformations in solution the globular form of BuIA displays activity at the nicotinic acetylcholine receptor, contrasting with the lack of activity of the structurally well-defined ribbon isomer. CONCLUSION: These findings are opposite to the general trends observed for alpha-conotoxins where the native isomers have well-defined structures and the ribbon isomers are generally disordered. This study thus highlights the influence of the disulfide connectivity of BuIA on the dynamics of the three-dimensional structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_17445276}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17445276 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17445276}}
==About this Structure==
==About this Structure==
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2NS3 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS3 OCA].
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2NS3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS3 OCA].
==Reference==
==Reference==
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[[Category: Ribbon disulfide connectivity]]
[[Category: Ribbon disulfide connectivity]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:28:53 2008''

Revision as of 15:28, 27 July 2008

Image:2ns3.png

Template:STRUCTURE 2ns3

Solution structure of ribbon BuIA

Template:ABSTRACT PUBMED 17445276

About this Structure

2NS3 is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics., Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL, BMC Struct Biol. 2007 Apr 20;7:28. PMID:17445276

Page seeded by OCA on Sun Jul 27 18:28:53 2008

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