This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ntn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ntn.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ntn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ntn| PDB=2ntn | SCENE= }}
{{STRUCTURE_2ntn| PDB=2ntn | SCENE= }}
-
'''Crystal structure of MabA-C60V/G139A/S144L'''
+
===Crystal structure of MabA-C60V/G139A/S144L===
-
==Overview==
+
<!--
-
The MabA protein from Mycobacterium tuberculosis is a validated drug target. Previous structural studies of this protein showed dynamic behaviour in the catalytic site and described motion between an open 'active' holo form (with NADP) and a closed 'inactive' apo form (without NADP). Here, a mutation (G139A) is reported that leads to complete protein inactivation and freezes the catalytic site into its closed form, even in the presence of the cofactor. This observation suggests a new way to develop anti-MabA drugs via protein stabilization of the 'inactive' form.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17642518}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17642518 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17642518}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Sdr]]
[[Category: Sdr]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:53:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:24:02 2008''

Revision as of 09:24, 29 July 2008

Image:2ntn.png

Template:STRUCTURE 2ntn

Crystal structure of MabA-C60V/G139A/S144L

Template:ABSTRACT PUBMED 17642518

About this Structure

2NTN is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies., Poncet-Montange G, Ducasse-Cabanot S, Quemard A, Labesse G, Cohen-Gonsaud M, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):923-5. Epub 2007, Jul 17. PMID:17642518

Page seeded by OCA on Tue Jul 29 12:24:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ntn"
Personal tools