2ntt

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[[Image:2ntt.gif|left|200px]]
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{{STRUCTURE_2ntt| PDB=2ntt | SCENE= }}
{{STRUCTURE_2ntt| PDB=2ntt | SCENE= }}
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'''Crystal Structure of SEK'''
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===Crystal Structure of SEK===
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==Overview==
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Superantigens (SAGs) interact with host immune receptors to induce a massive release of inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can be classified into five distinct evolutionary groups. Group V SAGs are characterized by the alpha3-beta8 loop, a unique approximately 15 amino acid residue extension that is required for optimal T cell activation. Here, we report the X-ray crystal structures of the group V SAG staphylococcal enterotoxin K (SEK) alone and in complex with the TCR hVbeta5.1 domain. SEK adopts a unique TCR binding orientation relative to other SAG-TCR complexes, which results in the alpha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR recognition site of SAGs. These interactions are absolutely required for TCR binding and T cell activation by SEK, and dictate the TCR Vbeta domain specificity of SEK and other group V SAGs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17560605 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17560605}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: T cell receptor]]
[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:54:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:41:30 2008''

Revision as of 15:41, 27 July 2008

Image:2ntt.png

Template:STRUCTURE 2ntt

Crystal Structure of SEK

Template:ABSTRACT PUBMED 17560605

About this Structure

2NTT is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A novel loop domain in superantigens extends their T cell receptor recognition site., Gunther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ, J Mol Biol. 2007 Aug 3;371(1):210-21. Epub 2007 May 18. PMID:17560605

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