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2nu5

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{{STRUCTURE_2nu5| PDB=2nu5 | SCENE= }}
{{STRUCTURE_2nu5| PDB=2nu5 | SCENE= }}
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'''Crystal structure of a complex of griffithsin cocrystallized with N-acetylglucosamine'''
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===Crystal structure of a complex of griffithsin cocrystallized with N-acetylglucosamine===
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==Overview==
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Crystal structures of complexes of an antiviral lectin griffithsin (GRFT) with glucose and N-acetylglucosamine were solved and refined at high resolution. In both complexes, all six monosaccharide-binding sites of GRFT were occupied and the mode of binding was similar to that of mannose. In our previous attempts to obtain a complex with N-acetylglucosamine by soaking, only a single site was occupied; thus, cocrystallization was clearly superior despite lower concentration of the ligand. Isothermal titration calorimetric experiments with N-acetylglucosamine, glucose, and mannose provided enthalpic evidence of distinct binding differences between the three monosaccharides. A comparison of the mode of binding of different monosaccharides is discussed in the context of the antiviral activity of GRFT, based on specific binding to high-mannose-containing complex carbohydrates found on viral envelopes.
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{{ABSTRACT_PUBMED_17567736}}
==About this Structure==
==About this Structure==
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[[Category: Mannose binding]]
[[Category: Mannose binding]]
[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:59:13 2008''

Revision as of 11:59, 28 July 2008

Image:2nu5.png

Template:STRUCTURE 2nu5

Crystal structure of a complex of griffithsin cocrystallized with N-acetylglucosamine

Template:ABSTRACT PUBMED 17567736

About this Structure

2NU5 is a Single protein structure of sequence from Griffithsia sp. q66d336. Full crystallographic information is available from OCA.

Reference

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine., Ziolkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A, Protein Sci. 2007 Jul;16(7):1485-9. Epub 2007 Jun 13. PMID:17567736

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