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1bgw
From Proteopedia
(New page: 200px<br /> <applet load="1bgw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bgw, resolution 2.7Å" /> '''TOPOISOMERASE RESIDU...) |
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| - | [[Image:1bgw.gif|left|200px]]<br /> | + | [[Image:1bgw.gif|left|200px]]<br /><applet load="1bgw" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bgw" size=" | + | |
caption="1bgw, resolution 2.7Å" /> | caption="1bgw, resolution 2.7Å" /> | ||
'''TOPOISOMERASE RESIDUES 410-1202,'''<br /> | '''TOPOISOMERASE RESIDUES 410-1202,'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of a large fragment of yeast type II DNA | + | The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws. |
==About this Structure== | ==About this Structure== | ||
| - | 1BGW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1BGW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http:// | + | 1BGW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1BGW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb73_1.html Topoisomerases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGW OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Topoisomerases]] | [[Category: Topoisomerases]] | ||
| - | [[Category: Berger, J | + | [[Category: Berger, J M.]] |
| - | [[Category: Gamblin, S | + | [[Category: Gamblin, S J.]] |
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J C.]] |
[[Category: dna-binding]] | [[Category: dna-binding]] | ||
[[Category: isomerase]] | [[Category: isomerase]] | ||
| Line 24: | Line 23: | ||
[[Category: topoisomerase]] | [[Category: topoisomerase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:08 2008'' |
Revision as of 09:55, 21 February 2008
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TOPOISOMERASE RESIDUES 410-1202,
Overview
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.
About this Structure
1BGW is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1BGW with [Topoisomerases]. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787
Page seeded by OCA on Thu Feb 21 11:55:08 2008
