2nx5

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[[Image:2nx5.gif|left|200px]]
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{{STRUCTURE_2nx5| PDB=2nx5 | SCENE= }}
{{STRUCTURE_2nx5| PDB=2nx5 | SCENE= }}
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'''Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A'''
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===Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A===
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==Overview==
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Plasticity of the T cell receptor (TCR) is a hallmark of major histocompatibility complex (MHC)-restricted T cell recognition. However, it is unclear whether interactions of TCR and peptide-MHC class I (pMHCI) always conform to this paradigm. Here we describe the structure of a TCR, ELS4, in its non-ligand-bound form and in complex with a prominent 'bulged' Epstein-Barr virus peptide bound to HLA-B(*)3501. This complex was atypical of previously characterized TCR-pMHCI interactions in that a rigid face of the TCR crumpled the bulged antigenic determinant. This peptide 'bulldozing' created a more featureless pMHCI determinant, allowing the TCR to maximize MHC class I contacts essential for MHC class I restriction of TCR recognition. Our findings represent a mechanism of antigen recognition whereby the plasticity of the T cell response is dictated mainly by adjustments in the MHC-bound peptide.
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(as it appears on PubMed at http://www.pubmed.gov), where 17259989 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17259989}}
==About this Structure==
==About this Structure==
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[[Category: Immune complex]]
[[Category: Immune complex]]
[[Category: Tcr-pmhc]]
[[Category: Tcr-pmhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:01:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:16:05 2008''

Revision as of 10:16, 28 July 2008

Image:2nx5.png

Template:STRUCTURE 2nx5

Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A

Template:ABSTRACT PUBMED 17259989

About this Structure

2NX5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule., Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J, Nat Immunol. 2007 Mar;8(3):268-76. Epub 2007 Jan 28. PMID:17259989

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