This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2nx5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2nx5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2nx5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nx5| PDB=2nx5 | SCENE= }}
{{STRUCTURE_2nx5| PDB=2nx5 | SCENE= }}
-
'''Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A'''
+
===Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A===
-
==Overview==
+
<!--
-
Plasticity of the T cell receptor (TCR) is a hallmark of major histocompatibility complex (MHC)-restricted T cell recognition. However, it is unclear whether interactions of TCR and peptide-MHC class I (pMHCI) always conform to this paradigm. Here we describe the structure of a TCR, ELS4, in its non-ligand-bound form and in complex with a prominent 'bulged' Epstein-Barr virus peptide bound to HLA-B(*)3501. This complex was atypical of previously characterized TCR-pMHCI interactions in that a rigid face of the TCR crumpled the bulged antigenic determinant. This peptide 'bulldozing' created a more featureless pMHCI determinant, allowing the TCR to maximize MHC class I contacts essential for MHC class I restriction of TCR recognition. Our findings represent a mechanism of antigen recognition whereby the plasticity of the T cell response is dictated mainly by adjustments in the MHC-bound peptide.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17259989}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17259989 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17259989}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Immune complex]]
[[Category: Immune complex]]
[[Category: Tcr-pmhc]]
[[Category: Tcr-pmhc]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:01:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:16:05 2008''

Revision as of 10:16, 28 July 2008

Image:2nx5.png

Template:STRUCTURE 2nx5

Crystal structure of ELS4 TCR bound to HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A

Template:ABSTRACT PUBMED 17259989

About this Structure

2NX5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule., Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J, Nat Immunol. 2007 Mar;8(3):268-76. Epub 2007 Jan 28. PMID:17259989

Page seeded by OCA on Mon Jul 28 13:16:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nx5"
Personal tools