2o27

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[[Image:2o27.gif|left|200px]]
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{{STRUCTURE_2o27| PDB=2o27 | SCENE= }}
{{STRUCTURE_2o27| PDB=2o27 | SCENE= }}
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'''Structure of a class III RTK signaling assembly'''
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===Structure of a class III RTK signaling assembly===
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==Overview==
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Stem cell factor (SCF) binds to and activates the KIT receptor, a class III receptor tyrosine kinase (RTK), to stimulate diverse processes including melanogenesis, gametogenesis and hematopoeisis. Dysregulation of KIT activation is associated with many cancers. We report a 2.5 A crystal structure of the functional core of SCF bound to the extracellular ligand-binding domains of KIT. The structure reveals a 'wrapping' SCF-recognition mode by KIT, in which KIT adopts a bent conformation to facilitate each of its first three immunoglobulin (Ig)-like domains to interact with SCF. Three surface epitopes on SCF, an extended loop, the B and C helices, and the N-terminal segment, contact distinct KIT domains, with two of the epitopes undergoing large conformational changes upon receptor binding. The SCF/KIT complex reveals a unique RTK dimerization assembly, and a novel recognition mode between four-helix bundle cytokines and Ig-family receptors. It serves as a framework for understanding the activation mechanisms of class III RTKs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17255936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17255936}}
==About this Structure==
==About this Structure==
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[[Category: Receptor/ligand complex]]
[[Category: Receptor/ligand complex]]
[[Category: Stem cell factor]]
[[Category: Stem cell factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:13:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:01:21 2008''

Revision as of 16:01, 27 July 2008

Image:2o27.png

Template:STRUCTURE 2o27

Structure of a class III RTK signaling assembly

Template:ABSTRACT PUBMED 17255936

About this Structure

2O27 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases., Liu H, Chen X, Focia PJ, He X, EMBO J. 2007 Feb 7;26(3):891-901. Epub 2007 Jan 25. PMID:17255936

Page seeded by OCA on Sun Jul 27 19:01:21 2008

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