2o3d

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[[Image:2o3d.gif|left|200px]]
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{{STRUCTURE_2o3d| PDB=2o3d | SCENE= }}
{{STRUCTURE_2o3d| PDB=2o3d | SCENE= }}
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'''Structure of human SF2/ASF RNA recognition motif 2 (RRM2)'''
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===Structure of human SF2/ASF RNA recognition motif 2 (RRM2)===
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==Overview==
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The serine/arginine-rich (SR) protein splicing factor 2/alternative splicing factor (SF2/ASF) has a role in splicing, stability, export and translation of messenger RNA. Here, we present the structure of the RNA recognition motif (RRM) 2 from SF2/ASF, which has an RRM fold with a considerably extended loop 5 region, containing a two-stranded beta-sheet. The loop 5 extension places the previously identified SR protein kinase 1 docking sequence largely within the RRM fold. We show that RRM2 binds to RNA in a new way, by using a tryptophan within a conserved SWQLKD motif that resides on helix alpha1, together with amino acids from strand beta2 and a histidine on loop 5. The linker connecting RRM1 and RRM2 contains arginine residues, which provide a binding site for the mRNA export factor TAP, and when TAP binds to this region it displaces RNA bound to RRM2.
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{{ABSTRACT_PUBMED_17668007}}
==About this Structure==
==About this Structure==
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2O3D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3D OCA].
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2O3D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3D OCA].
==Reference==
==Reference==
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[[Category: Rna binding protein]]
[[Category: Rna binding protein]]
[[Category: Rrm domain]]
[[Category: Rrm domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:16:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:06:49 2008''

Revision as of 20:06, 27 July 2008

Image:2o3d.png

Template:STRUCTURE 2o3d

Structure of human SF2/ASF RNA recognition motif 2 (RRM2)

Template:ABSTRACT PUBMED 17668007

About this Structure

2O3D is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural and functional analysis of RNA and TAP binding to SF2/ASF., Tintaru AM, Hautbergue GM, Hounslow AM, Hung ML, Lian LY, Craven CJ, Wilson SA, EMBO Rep. 2007 Aug;8(8):756-62. Epub 2007 Jul 13. PMID:17668007

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