2o4h

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{{STRUCTURE_2o4h| PDB=2o4h | SCENE= }}
{{STRUCTURE_2o4h| PDB=2o4h | SCENE= }}
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'''Human brain aspartoacylase complex with intermediate analog (N-phosphonomethyl-L-aspartate)'''
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===Human brain aspartoacylase complex with intermediate analog (N-phosphonomethyl-L-aspartate)===
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==Overview==
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Canavan disease is a fatal neurological disorder caused by the malfunctioning of a single metabolic enzyme, aspartoacylase, that catalyzes the deacetylation of N-acetyl- l-aspartate to produce l-aspartate and acetate. The structure of human brain aspartoacylase has been determined in complex with a stable tetrahedral intermediate analogue, N-phosphonomethyl- l-aspartate. This potent inhibitor forms multiple interactions between each of its heteroatoms and the substrate binding groups arrayed within the active site. The binding of the catalytic intermediate analogue induces the conformational ordering of several substrate binding groups, thereby setting up the active site for catalysis. The highly ordered binding of this inhibitor has allowed assignments to be made for substrate binding groups and provides strong support for a carboxypeptidase-type mechanism for the hydrolysis of the amide bond of the substrate, N-acetyl- l-aspartate.
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(as it appears on PubMed at http://www.pubmed.gov), where 18293939 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18293939}}
==About this Structure==
==About this Structure==
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[[Category: N-phosphonomethyl-l-aspartate]]
[[Category: N-phosphonomethyl-l-aspartate]]
[[Category: Zinc-dependent hydrolase]]
[[Category: Zinc-dependent hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:19:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:25:32 2008''

Revision as of 13:25, 29 July 2008

Image:2o4h.png

Template:STRUCTURE 2o4h

Human brain aspartoacylase complex with intermediate analog (N-phosphonomethyl-L-aspartate)

Template:ABSTRACT PUBMED 18293939

About this Structure

2O4H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue(,)., Le Coq J, Pavlovsky A, Malik R, Sanishvili R, Xu C, Viola RE, Biochemistry. 2008 Mar 18;47(11):3484-92. Epub 2008 Feb 23. PMID:18293939

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