1gyu

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(New page: 200px<br /> <applet load="1gyu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gyu, resolution 1.81&Aring;" /> '''GAMMA-ADAPTIN APPEN...)
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'''GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1'''<br />
'''GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1'''<br />
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==About this Structure==
==About this Structure==
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1GYU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1GYU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GYU OCA].
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1GYU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1GYU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYU OCA].
==Reference==
==Reference==
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[[Category: golgi]]
[[Category: golgi]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:01:09 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:54:56 2008''

Revision as of 13:54, 15 February 2008

Image:1gyu.jpg

1gyu, resolution 1.81Å

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GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1

Overview

The AP1 complex is one of a family of heterotetrameric clathrin-adaptor, complexes involved in vesicular trafficking between the Golgi and, endosomes. The complex has two large subunits, gamma and beta1, which can, be divided into trunk, hinge, and appendage domains. The 1.8 A resolution, structure of the gamma appendage is presented. The binding site for the, known gamma appendage ligand gamma-synergin is mapped through creation of, point mutations designed on the basis of the structure. We also show that, Eps15, a protein believed to be involved in vesicle formation at the, plasma membrane, is also a ligand of gamma appendage and binds to the same, site as gamma-synergin. This observation explains the demonstrated, brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi, complex.

About this Structure

1GYU is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1GYU with [Clathrin]. Full crystallographic information is available from OCA.

Reference

Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:12176391

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