2o5p

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{{STRUCTURE_2o5p| PDB=2o5p | SCENE= }}
{{STRUCTURE_2o5p| PDB=2o5p | SCENE= }}
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'''Crystal structure of the full length ferric pyoverdine outer membrane receptor FpvA of Pseudomonas aeruginosa in its apo form'''
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===Crystal structure of the full length ferric pyoverdine outer membrane receptor FpvA of Pseudomonas aeruginosa in its apo form===
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==Overview==
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Transport of molecules larger than 600 Da across the outer membrane involves TonB-dependent receptors and TonB-ExbB-ExbD of the inner membrane. The transport is energy consuming, and involves direct interactions between a short N-terminal sequence of receptor, called the TonB box, and TonB. We solved the structure of the ferric pyoverdine (Pvd-Fe) outer membrane receptor FpvA from Pseudomonas aeruginosa in its apo form. Structure analyses show that residues of the TonB box are in a beta strand which interacts through a mixed four-stranded beta sheet with the periplasmic signaling domain involved in interactions with an inner membrane sigma regulator. In this conformation, the TonB box cannot form a four-stranded beta sheet with TonB. The FhuA-TonB or BtuB-TonB structures show that the TonB-FpvA interactions require a conformational change which involves a beta strand lock-exchange mechanism. This mechanism is compatible with movements of the periplasmic domain deduced from crystallographic analyses of FpvA, FpvA-Pvd, and FpvA-Pvd-Fe.
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(as it appears on PubMed at http://www.pubmed.gov), where 17997964 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17997964}}
==About this Structure==
==About this Structure==
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[[Category: Pyoverdine]]
[[Category: Pyoverdine]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:21:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:35:13 2008''

Revision as of 12:35, 27 July 2008

Image:2o5p.png

Template:STRUCTURE 2o5p

Crystal structure of the full length ferric pyoverdine outer membrane receptor FpvA of Pseudomonas aeruginosa in its apo form

Template:ABSTRACT PUBMED 17997964

About this Structure

2O5P is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

A beta strand lock exchange for signal transduction in TonB-dependent transducers on the basis of a common structural motif., Brillet K, Journet L, Celia H, Paulus L, Stahl A, Pattus F, Cobessi D, Structure. 2007 Nov;15(11):1383-91. PMID:17997964

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