2o67

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{{STRUCTURE_2o67| PDB=2o67 | SCENE= }}
{{STRUCTURE_2o67| PDB=2o67 | SCENE= }}
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'''Crystal structure of Arabidopsis thaliana PII bound to malonate'''
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===Crystal structure of Arabidopsis thaliana PII bound to malonate===
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==Overview==
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The 1.9 A resolution crystal structure of PII from Arabidopsis thaliana reveals for the first time the molecular structure of a widely conserved regulator of carbon and nitrogen metabolism from a eukaryote. The structure provides a framework for understanding the arrangement of highly conserved residues shared with PII proteins from bacteria, archaea, and red algae as well as residues conserved only in plant PII. Most strikingly, a highly conserved segment at the N-terminus that is found only in plant PII forms numerous interactions with the alpha2 helix and projects from the surface of the homotrimer opposite to that occupied by the T-loop. In addition, solvent-exposed residues near the T-loop are highly conserved in plants but differ in prokaryotes. Several residues at the C-terminus that are also highly conserved only in plants contribute part of the ATP-binding site and likely participate in an ATP-induced conformational change. Structures of PII also reveal how citrate and malonate bind near the triphosphate binding site occupied by ATP in bacterial and archaeal PII proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_17279613}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17279613 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17279613}}
==About this Structure==
==About this Structure==
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[[Category: Ng, K K.S.]]
[[Category: Ng, K K.S.]]
[[Category: Regulation of nitrogen and carbon metabolism]]
[[Category: Regulation of nitrogen and carbon metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:22:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:30:09 2008''

Revision as of 11:30, 29 July 2008

Image:2o67.png

Template:STRUCTURE 2o67

Crystal structure of Arabidopsis thaliana PII bound to malonate

Template:ABSTRACT PUBMED 17279613

About this Structure

2O67 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Crystal structure of Arabidopsis PII reveals novel structural elements unique to plants., Mizuno Y, Berenger B, Moorhead GB, Ng KK, Biochemistry. 2007 Feb 13;46(6):1477-83. PMID:17279613

Page seeded by OCA on Tue Jul 29 14:30:09 2008

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