2o71

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{{STRUCTURE_2o71| PDB=2o71 | SCENE= }}
{{STRUCTURE_2o71| PDB=2o71 | SCENE= }}
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'''Crystal structure of RAIDD DD'''
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===Crystal structure of RAIDD DD===
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==Overview==
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Caspase-2 is implicated in stress-induced apoptosis that acts as an upstream initiator of mitochondrial permeabilization. Recent studies have shown that caspase-2 activation requires a molecular complex known as the PIDDosome comprising the p53-inducible protein PIDD, the adapter protein RAIDD and caspase-2. RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2 and a C-terminal death domain (DD) that interacts with the DD in PIDD. As a first step towards elucidating the molecular mechanisms of caspase-2 activation, we report the crystal structure of RAIDD DD at 2.0 A resolution. The high-resolution structure reveals important features of RAIDD DD that may be important for DD folding and dynamics and for assembly of the PIDDosome.
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(as it appears on PubMed at http://www.pubmed.gov), where 16434054 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16434054}}
==About this Structure==
==About this Structure==
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[[Category: Death domain]]
[[Category: Death domain]]
[[Category: Raidd]]
[[Category: Raidd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:24:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:12:21 2008''

Revision as of 17:12, 28 July 2008

Image:2o71.png

Template:STRUCTURE 2o71

Crystal structure of RAIDD DD

Template:ABSTRACT PUBMED 16434054

About this Structure

2O71 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly., Park HH, Wu H, J Mol Biol. 2006 Mar 24;357(2):358-64. Epub 2006 Jan 11. PMID:16434054

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