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2oaj

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[[Image:2oaj.jpg|left|200px]]
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{{STRUCTURE_2oaj| PDB=2oaj | SCENE= }}
{{STRUCTURE_2oaj| PDB=2oaj | SCENE= }}
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'''Crystal structure of Sro7 from S. cerevisiae'''
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===Crystal structure of Sro7 from S. cerevisiae===
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==Overview==
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Polarized exocytosis requires coordination between the actin cytoskeleton and the exocytic machinery responsible for fusion of secretory vesicles at specific sites on the plasma membrane. Fusion requires formation of a complex between a vesicle-bound R-SNARE and plasma membrane Qa, Qb and Qc SNARE proteins. Proteins in the lethal giant larvae protein family, including lethal giant larvae and tomosyn in metazoans and Sro7 in yeast, interact with Q-SNAREs and are emerging as key regulators of polarized exocytosis. The crystal structure of Sro7 reveals two seven-bladed WD40 beta-propellers followed by a 60-residue-long 'tail', which is bound to the surface of the amino-terminal propeller. Deletion of the Sro7 tail enables binding to the Qbc SNARE region of Sec9 and this interaction inhibits SNARE complex assembly. The N-terminal domain of Sec9 provides a second, high-affinity Sro7 interaction that is unaffected by the tail. The results suggest that Sro7 acts as an allosteric regulator of exocytosis through interactions with factors that control the tail. Sequence alignments indicate that lethal giant larvae and tomosyn have a two-beta-propeller fold similar to that of Sro7, but only tomosyn appears to retain the regulatory tail.
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(as it appears on PubMed at http://www.pubmed.gov), where 17392788 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17392788}}
==About this Structure==
==About this Structure==
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[[Category: Endocytosis/exocytosis complex]]
[[Category: Endocytosis/exocytosis complex]]
[[Category: Wd40 repeat]]
[[Category: Wd40 repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:31:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:00:41 2008''

Revision as of 20:00, 27 July 2008

Image:2oaj.png

Template:STRUCTURE 2oaj

Crystal structure of Sro7 from S. cerevisiae

Template:ABSTRACT PUBMED 17392788

About this Structure

2OAJ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism., Hattendorf DA, Andreeva A, Gangar A, Brennwald PJ, Weis WI, Nature. 2007 Mar 29;446(7135):567-71. PMID:17392788

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