2obd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2obd.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2obd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2obd| PDB=2obd | SCENE= }}
{{STRUCTURE_2obd| PDB=2obd | SCENE= }}
-
'''Crystal Structure of Cholesteryl Ester Transfer Protein'''
+
===Crystal Structure of Cholesteryl Ester Transfer Protein===
-
==Overview==
+
<!--
-
Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species. Inhibition of CETP raises HDL cholesterol and may potentially be used to treat cardiovascular disease. Here we describe the structure of CETP at 2.2-A resolution, revealing a 60-A-long tunnel filled with two hydrophobic cholesteryl esters and plugged by an amphiphilic phosphatidylcholine at each end. The two tunnel openings are large enough to allow lipid access, which is aided by a flexible helix and possibly also by a mobile flap. The curvature of the concave surface of CETP matches the radius of curvature of HDL particles, and potential conformational changes may occur to accommodate larger lipoprotein particles. Point mutations blocking the middle of the tunnel abolish lipid-transfer activities, suggesting that neutral lipids pass through this continuous tunnel.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17237796}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17237796 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17237796}}
==Disease==
==Disease==
Line 28: Line 32:
[[Category: Cholesteryl ester]]
[[Category: Cholesteryl ester]]
[[Category: Lipid transfer protein]]
[[Category: Lipid transfer protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:33:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:18:22 2008''

Revision as of 14:18, 27 July 2008


PDB ID 2obd

Drag the structure with the mouse to rotate
2obd, resolution 2.10Å ()
Ligands: , , , , , , ,
Gene: CETP (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

Crystal Structure of Cholesteryl Ester Transfer Protein

Template:ABSTRACT PUBMED 17237796

Disease

Known disease associated with this structure: Hyperalphalipoproteinemia OMIM:[118470], CETP deficiency OMIM:[118470], High density lipoprotein cholesterol level QTL 10 OMIM:[118470], Longevity, exceptional OMIM:[118470]

About this Structure

2OBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules., Qiu X, Mistry A, Ammirati MJ, Chrunyk BA, Clark RW, Cong Y, Culp JS, Danley DE, Freeman TB, Geoghegan KF, Griffor MC, Hawrylik SJ, Hayward CM, Hensley P, Hoth LR, Karam GA, Lira ME, Lloyd DB, McGrath KM, Stutzman-Engwall KJ, Subashi AK, Subashi TA, Thompson JF, Wang IK, Zhao H, Seddon AP, Nat Struct Mol Biol. 2007 Feb;14(2):106-13. Epub 2007 Jan 21. PMID:17237796

Page seeded by OCA on Sun Jul 27 17:18:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2obd"
Personal tools