2obl

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{{STRUCTURE_2obl| PDB=2obl | SCENE= }}
{{STRUCTURE_2obl| PDB=2obl | SCENE= }}
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'''Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria'''
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===Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria===
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==Overview==
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The type III secretion system (T3SS) ATPase is the conserved and essential inner-membrane component involved in the initial stages of selective secretion of specialized T3SS virulence effector proteins from the bacterial cytoplasm through to the infected host cell, a process crucial to subsequent pathogenicity. Here we present the 1.8-A-resolution crystal structure of the catalytic domain of the prototypical T3SS ATPase EscN from enteropathogenic Escherichia coli (EPEC). Along with in vitro and in vivo mutational analysis, our data show that the T3SS ATPases share similarity with the F1 ATPases but have important structural and sequence differences that dictate their unique secretory role. We also show that T3SS ATPase activity is dependent on EscN oligomerization and describe the molecular features and possible functional implications of a hexameric ring model.
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(as it appears on PubMed at http://www.pubmed.gov), where 17237797 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17237797}}
==About this Structure==
==About this Structure==
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[[Category: Zarivach, R.]]
[[Category: Zarivach, R.]]
[[Category: Atpase]]
[[Category: Atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:31:18 2008''

Revision as of 21:31, 27 July 2008

Image:2obl.png

Template:STRUCTURE 2obl

Structural and biochemical analysis of a prototypical ATPase from the type III secretion system of pathogenic bacteria

Template:ABSTRACT PUBMED 17237797

About this Structure

2OBL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural analysis of a prototypical ATPase from the type III secretion system., Zarivach R, Vuckovic M, Deng W, Finlay BB, Strynadka NC, Nat Struct Mol Biol. 2007 Feb;14(2):131-7. Epub 2007 Jan 21. PMID:17237797

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