1ruz
From Proteopedia
(New page: 200px<br /> <applet load="1ruz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ruz, resolution 2.9Å" /> '''1918 H1 Hemagglutini...) |
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| - | [[Image:1ruz.gif|left|200px]]<br /> | + | [[Image:1ruz.gif|left|200px]]<br /><applet load="1ruz" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ruz" size=" | + | |
caption="1ruz, resolution 2.9Å" /> | caption="1ruz, resolution 2.9Å" /> | ||
'''1918 H1 Hemagglutinin'''<br /> | '''1918 H1 Hemagglutinin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The 1918 influenza pandemic resulted in about 20 million deaths. This | + | The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population. |
==About this Structure== | ==About this Structure== | ||
| - | 1RUZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with NDG and NAG as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1RUZ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http:// | + | 1RUZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1RUZ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Daniels, R | + | [[Category: Daniels, R S.]] |
| - | [[Category: Gamblin, S | + | [[Category: Gamblin, S J.]] |
[[Category: Ha, Y.]] | [[Category: Ha, Y.]] | ||
| - | [[Category: Haire, L | + | [[Category: Haire, L F.]] |
| - | [[Category: Russell, R | + | [[Category: Russell, R J.]] |
| - | [[Category: Skehel, J | + | [[Category: Skehel, J J.]] |
| - | [[Category: Steinhauer, D | + | [[Category: Steinhauer, D A.]] |
| - | [[Category: Stevens, D | + | [[Category: Stevens, D J.]] |
[[Category: Vasisht, N.]] | [[Category: Vasisht, N.]] | ||
[[Category: Xiao, B.]] | [[Category: Xiao, B.]] | ||
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[[Category: influenza a virus]] | [[Category: influenza a virus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:49 2008'' |
Revision as of 12:54, 21 February 2008
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1918 H1 Hemagglutinin
Overview
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
About this Structure
1RUZ is a Protein complex structure of sequences from Influenza a virus with and as ligands. The following page contains interesting information on the relation of 1RUZ with [Hemagglutinin]. Full crystallographic information is available from OCA.
Reference
The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886
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