We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2oex

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oex.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2oex.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oex| PDB=2oex | SCENE= }}
{{STRUCTURE_2oex| PDB=2oex | SCENE= }}
-
'''Structure of ALIX/AIP1 V Domain'''
+
===Structure of ALIX/AIP1 V Domain===
-
==Overview==
+
<!--
-
ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is composed of two extended three-helix bundles that form elongated arms that fold back into a "V." The structures also reveal conformational flexibility in the arms that suggests that the V domain may act as a flexible hinge in response to ligand binding. YPX(n)L late domains bind in a conserved hydrophobic pocket on the second arm near the apex of the V, whereas CHMP4/ESCRT-III proteins bind a conserved hydrophobic patch on the Bro1 domain, and both interactions are required for virus budding. ALIX therefore serves as a flexible, extended scaffold that connects retroviral Gag proteins to ESCRT-III and other cellular-budding machinery.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17350572}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17350572 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17350572}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Zhai, Q.]]
[[Category: Zhai, Q.]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:45:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:39:21 2008''

Revision as of 03:39, 29 July 2008

Image:2oex.png

Template:STRUCTURE 2oex

Structure of ALIX/AIP1 V Domain

Template:ABSTRACT PUBMED 17350572

About this Structure

2OEX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding., Fisher RD, Chung HY, Zhai Q, Robinson H, Sundquist WI, Hill CP, Cell. 2007 Mar 9;128(5):841-52. PMID:17350572

Page seeded by OCA on Tue Jul 29 06:39:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oex"
Personal tools