2ogz

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[[Image:2ogz.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2ogz| PDB=2ogz | SCENE= }}
{{STRUCTURE_2ogz| PDB=2ogz | SCENE= }}
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'''Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor'''
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===Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor===
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==Overview==
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A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70 degrees side-chain rotation to accommodate the inhibitor and allows access to a previously unexposed area of the protein backbone for hydrogen bonding.
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(as it appears on PubMed at http://www.pubmed.gov), where 17239592 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17239592}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:53:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:31:15 2008''

Revision as of 12:31, 28 July 2008

Image:2ogz.png

Template:STRUCTURE 2ogz

Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor

Template:ABSTRACT PUBMED 17239592

About this Structure

2OGZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site., Sheehan SM, Mest HJ, Watson BM, Klimkowski VJ, Timm DE, Cauvin A, Parsons SH, Shi Q, Canada EJ, Wiley MR, Ruehter G, Evers B, Petersen S, Blaszczak LC, Pulley SR, Margolis BJ, Wishart GN, Renson B, Hankotius D, Mohr M, Zechel JC, Michael Kalbfleisch J, Dingess-Hammond EA, Boelke A, Weichert AG, Bioorg Med Chem Lett. 2007 Mar 15;17(6):1765-8. Epub 2006 Dec 24. PMID:17239592

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