1y0j
From Proteopedia
(New page: 200px<br /> <applet load="1y0j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y0j" /> '''Zinc fingers as protein recognition motifs:...) |
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'''Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction'''<br /> | '''Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction'''<br /> | ||
==Overview== | ==Overview== | ||
| - | GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that | + | GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact to play essential roles in erythroid and megakaryocytic development. Several naturally occurring mutations in the GATA-1 gene that alter the FOG-binding domain have been reported. The mutations are associated with familial anemias and thrombocytopenias of differing severity. To elucidate the molecular basis for the GATA-1/FOG interaction, we have determined the three-dimensional structure of a complex comprising the interaction domains of these proteins. The structure reveals how zinc fingers can act as protein recognition motifs. Details of the architecture of the contact domains and their physical properties provide a molecular explanation for how the GATA-1 mutations contribute to distinct but related genetic diseases. |
==About this Structure== | ==About this Structure== | ||
| - | 1Y0J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1Y0J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http:// | + | 1Y0J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1Y0J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0J OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Zinc Fingers]] | [[Category: Zinc Fingers]] | ||
| - | [[Category: Crofts, L | + | [[Category: Crofts, L A.]] |
[[Category: Crossley, M.]] | [[Category: Crossley, M.]] | ||
| - | [[Category: Kwan, A | + | [[Category: Kwan, A H.Y.]] |
| - | [[Category: Liew, C | + | [[Category: Liew, C K.]] |
| - | [[Category: Loughlin, F | + | [[Category: Loughlin, F E.]] |
| - | [[Category: Mackay, J | + | [[Category: Mackay, J P.]] |
| - | [[Category: Matthews, J | + | [[Category: Matthews, J M.]] |
| - | [[Category: Simpson, R | + | [[Category: Simpson, R J.Y.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: fog]] | [[Category: fog]] | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:00:32 2008'' |
Revision as of 14:00, 21 February 2008
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Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction
Overview
GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact to play essential roles in erythroid and megakaryocytic development. Several naturally occurring mutations in the GATA-1 gene that alter the FOG-binding domain have been reported. The mutations are associated with familial anemias and thrombocytopenias of differing severity. To elucidate the molecular basis for the GATA-1/FOG interaction, we have determined the three-dimensional structure of a complex comprising the interaction domains of these proteins. The structure reveals how zinc fingers can act as protein recognition motifs. Details of the architecture of the contact domains and their physical properties provide a molecular explanation for how the GATA-1 mutations contribute to distinct but related genetic diseases.
About this Structure
1Y0J is a Protein complex structure of sequences from Drosophila melanogaster and Mus musculus with as ligand. The following page contains interesting information on the relation of 1Y0J with [Zinc Fingers]. Full crystallographic information is available from OCA.
Reference
Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction., Liew CK, Simpson RJ, Kwan AH, Crofts LA, Loughlin FE, Matthews JM, Crossley M, Mackay JP, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):583-8. Epub 2005 Jan 11. PMID:15644435
Page seeded by OCA on Thu Feb 21 16:00:32 2008
