2oit

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{{STRUCTURE_2oit| PDB=2oit | SCENE= }}
{{STRUCTURE_2oit| PDB=2oit | SCENE= }}
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'''Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN'''
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===Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN===
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==Overview==
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The mammalian nuclear pore complex (NPC) is an approximately 120-MDa proteinaceous assembly consisting of approximately 30 proteins and is the sole gate in the nuclear envelope. The human protooncogene Nup214 was first identified as a target for chromosomal translocation involved in leukemogenesis. Nup214 is located on the cytoplasmic face of the NPC and is implicated in anchoring the cytoplasmic filaments of the NPC and recruiting the RNA helicase Ddx19. Here, we present the crystal structure of the human Nup214 N-terminal domain at 1.65-A resolution. The structure reveals a seven-bladed beta-propeller followed by a 30-residue C-terminal extended peptide segment, which folds back onto the beta-propeller and binds to its bottom face. The beta-propeller repeats lack any recognizable sequence motif and are distinguished by extensive insertions between the canonical beta-strands. We propose a mechanism by which the C-terminal peptide extension is involved in NPC assembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 17264208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17264208}}
==Disease==
==Disease==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:00:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:08:18 2008''

Revision as of 01:08, 29 July 2008

Image:2oit.png

Template:STRUCTURE 2oit

Contents

Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN

Template:ABSTRACT PUBMED 17264208

Disease

Known disease associated with this structure: Leukemia, T-cell acute lymphoblastic OMIM:[114350], Leukemia, acute myeloid OMIM:[114350]

About this Structure

2OIT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN., Napetschnig J, Blobel G, Hoelz A, Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1783-8. Epub 2007 Jan 30. PMID:17264208

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