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2oiu

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{{STRUCTURE_2oiu| PDB=2oiu | SCENE= }}
{{STRUCTURE_2oiu| PDB=2oiu | SCENE= }}
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'''L1 Ribozyme Ligase circular adduct'''
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===L1 Ribozyme Ligase circular adduct===
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==Overview==
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Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA fragments. Invariant residues form tertiary contacts that stabilize a flexible stem of the ribozyme at the ligation site, where an essential magnesium ion coordinates three phosphates. The structure of the active site permits us to suggest how transition-state stabilization and a general base may catalyze the ligation reaction required for prebiotic RNA assembly.
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{{ABSTRACT_PUBMED_17363667}}
==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:00:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:28:23 2008''

Revision as of 05:28, 28 July 2008

Image:2oiu.png

Template:STRUCTURE 2oiu

L1 Ribozyme Ligase circular adduct

Template:ABSTRACT PUBMED 17363667

About this Structure

Full crystallographic information is available from OCA.

Reference

The structural basis of ribozyme-catalyzed RNA assembly., Robertson MP, Scott WG, Science. 2007 Mar 16;315(5818):1549-53. PMID:17363667

Page seeded by OCA on Mon Jul 28 08:28:23 2008

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