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2oiv

From Proteopedia

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{{STRUCTURE_2oiv| PDB=2oiv | SCENE= }}
{{STRUCTURE_2oiv| PDB=2oiv | SCENE= }}
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'''Structural Analysis of Xanthomonas XopD Provides Insights Into Substrate Specificity of Ubiquitin-like Protein Proteases'''
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===Structural Analysis of Xanthomonas XopD Provides Insights Into Substrate Specificity of Ubiquitin-like Protein Proteases===
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==Overview==
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XopD (Xanthomonas outer protein D), a type III secreted effector from Xanthomonas campestris pv. vesicatoria, is a desumoylating enzyme with strict specificity for its plant small ubiquitin-like modifier (SUMO) substrates. Based on SUMO sequence alignments and peptidase assays with various plant, yeast, and mammalian SUMOs, we identified residues in SUMO that contribute to XopD/SUMO recognition. Further predictions regarding the enzyme/substrate specificity were made by solving the XopD crystal structure. By incorporating structural information with sequence alignments and enzyme assays, we were able to elucidate determinants of the rigid SUMO specificity exhibited by the Xanthomonas virulence factor XopD.
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{{ABSTRACT_PUBMED_17204475}}
==About this Structure==
==About this Structure==
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[[Category: Secreted virulence factor]]
[[Category: Secreted virulence factor]]
[[Category: Type iii secreted effector]]
[[Category: Type iii secreted effector]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:19:04 2008''

Revision as of 14:19, 27 July 2008

Image:2oiv.png

Template:STRUCTURE 2oiv

Structural Analysis of Xanthomonas XopD Provides Insights Into Substrate Specificity of Ubiquitin-like Protein Proteases

Template:ABSTRACT PUBMED 17204475

About this Structure

2OIV is a Single protein structure of sequence from Xanthomonas euvesicatoria. Full crystallographic information is available from OCA.

Reference

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases., Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K, J Biol Chem. 2007 Mar 2;282(9):6773-82. Epub 2007 Jan 3. PMID:17204475

Page seeded by OCA on Sun Jul 27 17:19:04 2008

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