This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2okv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2okv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2okv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2okv| PDB=2okv | SCENE= }}
{{STRUCTURE_2okv| PDB=2okv | SCENE= }}
-
'''c-Myc DNA Unwinding Element Binding Protein'''
+
===c-Myc DNA Unwinding Element Binding Protein===
-
==Overview==
+
<!--
-
Local zones of easily unwound DNA are characteristic of prokaryotic and eukaryotic replication origins. The DNA-unwinding element of the human c-myc replication origin is essential for replicator activity and is a target of the DNA-unwinding element-binding protein DUE-B in vivo. We present here the 2.0A crystal structure of DUE-B and complementary biochemical characterization of its biological activity. The structure corresponds to a dimer of the N-terminal domain of the full-length protein and contains many of the structural elements of the nucleotide binding fold. A single magnesium ion resides in the putative active site cavity, which could serve to facilitate ATP hydrolytic activity of this protein. The structure also demonstrates a notable similarity to those of tRNA-editing enzymes. Consistent with this structural homology, the N-terminal core of DUE-B is shown to display both D-aminoacyl-tRNA deacylase activity and ATPase activity. We further demonstrate that the C-terminal portion of the enzyme is disordered and not essential for dimerization. However, this region is essential for DNA binding in vitro and becomes ordered in the presence of DNA.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17264083}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17264083 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17264083}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Due]]
[[Category: Due]]
[[Category: Trna deacylase]]
[[Category: Trna deacylase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:07:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:09:15 2008''

Revision as of 16:09, 28 July 2008

Image:2okv.png

Template:STRUCTURE 2okv

c-Myc DNA Unwinding Element Binding Protein

Template:ABSTRACT PUBMED 17264083

About this Structure

2OKV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B., Kemp M, Bae B, Yu JP, Ghosh M, Leffak M, Nair SK, J Biol Chem. 2007 Apr;282(14):10441-8. Epub 2007 Jan 30. PMID:17264083

Page seeded by OCA on Mon Jul 28 19:09:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2okv"
Personal tools