2okv

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{{STRUCTURE_2okv| PDB=2okv | SCENE= }}
{{STRUCTURE_2okv| PDB=2okv | SCENE= }}
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'''c-Myc DNA Unwinding Element Binding Protein'''
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===c-Myc DNA Unwinding Element Binding Protein===
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==Overview==
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Local zones of easily unwound DNA are characteristic of prokaryotic and eukaryotic replication origins. The DNA-unwinding element of the human c-myc replication origin is essential for replicator activity and is a target of the DNA-unwinding element-binding protein DUE-B in vivo. We present here the 2.0A crystal structure of DUE-B and complementary biochemical characterization of its biological activity. The structure corresponds to a dimer of the N-terminal domain of the full-length protein and contains many of the structural elements of the nucleotide binding fold. A single magnesium ion resides in the putative active site cavity, which could serve to facilitate ATP hydrolytic activity of this protein. The structure also demonstrates a notable similarity to those of tRNA-editing enzymes. Consistent with this structural homology, the N-terminal core of DUE-B is shown to display both D-aminoacyl-tRNA deacylase activity and ATPase activity. We further demonstrate that the C-terminal portion of the enzyme is disordered and not essential for dimerization. However, this region is essential for DNA binding in vitro and becomes ordered in the presence of DNA.
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{{ABSTRACT_PUBMED_17264083}}
==About this Structure==
==About this Structure==
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[[Category: Due]]
[[Category: Due]]
[[Category: Trna deacylase]]
[[Category: Trna deacylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:07:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:09:15 2008''

Revision as of 16:09, 28 July 2008

Image:2okv.png

Template:STRUCTURE 2okv

c-Myc DNA Unwinding Element Binding Protein

Template:ABSTRACT PUBMED 17264083

About this Structure

2OKV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B., Kemp M, Bae B, Yu JP, Ghosh M, Leffak M, Nair SK, J Biol Chem. 2007 Apr;282(14):10441-8. Epub 2007 Jan 30. PMID:17264083

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