2ont

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{{STRUCTURE_2ont| PDB=2ont | SCENE= }}
{{STRUCTURE_2ont| PDB=2ont | SCENE= }}
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'''A swapped dimer of the HIV-1 capsid C-terminal domain'''
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===A swapped dimer of the HIV-1 capsid C-terminal domain===
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==Overview==
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Assembly of the HIV and other retroviruses is primarily driven by the oligomerization of the Gag polyprotein, the major viral structural protein capable of forming virus-like particles even in the absence of all other virally encoded components. Several critical determinants of Gag oligomerization are located in the C-terminal domain of the capsid protein (CA-CTD), which encompasses the most conserved segment in the highly variable Gag protein called the major homology region (MHR). The CA-CTD is thought to function as a dimerization module, although the existing model of CA-CTD dimerization does not readily explain why the conserved residues of the MHR are essential for retroviral assembly. Here we describe an x-ray structure of a distinct domain-swapped variant of the HIV-1 CA-CTD dimer stabilized by a single amino acid deletion. In the domain-swapped structure, the MHR-containing segment forms a major part of the dimerization interface, providing a structural mechanism for the enigmatic function of the MHR in HIV assembly. Our observations suggest that swapping of the MHR segments of adjacent Gag molecules may be a critical intermediate in retroviral assembly.
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The line below this paragraph, {{ABSTRACT_PUBMED_17360528}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17360528 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17360528}}
==About this Structure==
==About this Structure==
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[[Category: Gag]]
[[Category: Gag]]
[[Category: Hiv]]
[[Category: Hiv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:17:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:26:42 2008''

Revision as of 11:26, 29 July 2008

Image:2ont.png

Template:STRUCTURE 2ont

A swapped dimer of the HIV-1 capsid C-terminal domain

Template:ABSTRACT PUBMED 17360528

About this Structure

2ONT is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Domain-swapped dimerization of the HIV-1 capsid C-terminal domain., Ivanov D, Tsodikov OV, Kasanov J, Ellenberger T, Wagner G, Collins T, Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4353-8. Epub 2007 Mar 5. PMID:17360528

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