2oo4

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{{STRUCTURE_2oo4| PDB=2oo4 | SCENE= }}
{{STRUCTURE_2oo4| PDB=2oo4 | SCENE= }}
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'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''
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===Structure of LNR-HD (Negative Regulatory Region) from human Notch 2===
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==Overview==
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Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.
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(as it appears on PubMed at http://www.pubmed.gov), where 17401372 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17401372}}
==Disease==
==Disease==
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[[Category: Lnr]]
[[Category: Lnr]]
[[Category: Sea domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:18:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:57:13 2008''

Revision as of 04:57, 28 July 2008

Image:2oo4.png

Template:STRUCTURE 2oo4

Contents

Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

Template:ABSTRACT PUBMED 17401372

Disease

Known disease associated with this structure: Alagille syndrome 2 OMIM:[600275]

About this Structure

2OO4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372

Page seeded by OCA on Mon Jul 28 07:57:13 2008

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