We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2oq9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oq9.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2oq9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oq9| PDB=2oq9 | SCENE= }}
{{STRUCTURE_2oq9| PDB=2oq9 | SCENE= }}
-
'''Structure of the non-canonical Mcol5 of Hydra nematocysts'''
+
===Structure of the non-canonical Mcol5 of Hydra nematocysts===
-
==Overview==
+
<!--
-
Minicollagens constitute a family of unusually short collagen molecules isolated from cnidarians. They are restricted to the nematocyst, a cylindrical explosive organelle serving in defense and capture of prey. The nematocyst capsule contains a long tubule inside of its matrix, which is expelled and everted during an ultrafast discharge process. Here, we report the cloning and characterization of a novel minicollagen in Hydra, designated minicollagen-15 (NCol-15). NCol-15, like NCol-3 and NCol-4, shows deviations from the canonical cysteine pattern in its terminal cysteine-rich domains (CRDs). Minicollagens share common domain architectures with a central collagen sequence flanked by polyproline stretches and short N- and C-terminal CRDs. The CRDs are involved in the formation of a highly resistant cysteine network, which constitutes the basic structure of the nematocyst capsule. Unlike NCol-1, which is part of the capsule wall, NCol-15 is localized to tubules, arguing for a functional differentiation of minicollagens within the nematocyst architecture. NMR analysis of the altered C-terminal CRD of NCol-15 showed a novel disulfide-linked structure within the cysteine-containing region exhibiting similar folding kinetics and stability as the canonical CRDs. Our data provide evidence for evolutionary diversification among minicollagens, which probably facilitated alterations in the morphology of the nematocyst wall and tubule.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18206162}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18206162 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18206162}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQ9 OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQ9 OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Non-canonical crd]]
[[Category: Non-canonical crd]]
[[Category: Structural protein]]
[[Category: Structural protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:26:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:06:06 2008''

Revision as of 02:06, 29 July 2008

Image:2oq9.png

Template:STRUCTURE 2oq9

Structure of the non-canonical Mcol5 of Hydra nematocysts

Template:ABSTRACT PUBMED 18206162

About this Structure

Full experimental information is available from OCA.

Reference

Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts., Adamczyk P, Meier S, Gross T, Hobmayer B, Grzesiek S, Bachinger HP, Holstein TW, Ozbek S, J Mol Biol. 2008 Feb 29;376(4):1008-20. Epub 2007 Dec 5. PMID:18206162

Page seeded by OCA on Tue Jul 29 05:06:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oq9"
Personal tools