2otl

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{{STRUCTURE_2otl| PDB=2otl | SCENE= }}
{{STRUCTURE_2otl| PDB=2otl | SCENE= }}
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'''Girodazole bound to the large subunit of Haloarcula marismortui'''
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===Girodazole bound to the large subunit of Haloarcula marismortui===
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==Overview==
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Crystal structures of the 50 S ribosomal subunit from Haloarcula marismortui complexed with two antibiotics have identified new sites at which antibiotics interact with the ribosome and inhibit protein synthesis. 13-Deoxytedanolide binds to the E site of the 50 S subunit at the same location as the CCA of tRNA, and thus appears to inhibit protein synthesis by competing with deacylated tRNAs for E site binding. Girodazole binds near the E site region, but is somewhat buried and may inhibit tRNA binding by interfering with conformational changes that occur at the E site. The specificity of 13-deoxytedanolide for eukaryotic ribosomes is explained by its extensive interactions with protein L44e, which is an E site component of archaeal and eukaryotic ribosomes, but not of eubacterial ribosomes. In addition, protein L28, which is unique to the eubacterial E site, overlaps the site occupied by 13-deoxytedanolide, precluding its binding to eubacterial ribosomes. Girodazole is specific for eukarytes and archaea because it makes interactions with L15 that are not possible in eubacteria.
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{{ABSTRACT_PUBMED_17321546}}
==About this Structure==
==About this Structure==
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[[Category: Large subunit]]
[[Category: Large subunit]]
[[Category: Ribosome]]
[[Category: Ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:36:09 2008''

Revision as of 21:36, 27 July 2008

Image:2otl.png

Template:STRUCTURE 2otl

Girodazole bound to the large subunit of Haloarcula marismortui

Template:ABSTRACT PUBMED 17321546

About this Structure

2OTL is a Protein complex structure of sequences from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole., Schroeder SJ, Blaha G, Tirado-Rives J, Steitz TA, Moore PB, J Mol Biol. 2007 Apr 13;367(5):1471-9. Epub 2007 Feb 7. PMID:17321546

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