2oug

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{{STRUCTURE_2oug| PDB=2oug | SCENE= }}
{{STRUCTURE_2oug| PDB=2oug | SCENE= }}
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'''Crystal structure of the RfaH transcription factor at 2.1A resolution'''
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===Crystal structure of the RfaH transcription factor at 2.1A resolution===
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==Overview==
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RfaH, a paralog of the general transcription factor NusG, is recruited to elongating RNA polymerase at specific regulatory sites. The X-ray structure of Escherichia coli RfaH reported here reveals two domains. The N-terminal domain displays high similarity to that of NusG. In contrast, the alpha-helical coiled-coil C domain, while retaining sequence similarity, is strikingly different from the beta barrel of NusG. To our knowledge, such an all-beta to all-alpha transition of the entire domain is the most extreme example of protein fold evolution known to date. Both N domains possess a vast hydrophobic cavity that is buried by the C domain in RfaH but is exposed in NusG. We propose that this cavity constitutes the RNA polymerase-binding site, which becomes unmasked in RfaH only upon sequence-specific binding to the nontemplate DNA strand that triggers domain dissociation. Finally, we argue that RfaH binds to the beta' subunit coiled coil, the major target site for the initiation sigma factors.
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The line below this paragraph, {{ABSTRACT_PUBMED_17434131}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17434131 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17434131}}
==About this Structure==
==About this Structure==
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[[Category: Transcription pausing]]
[[Category: Transcription pausing]]
[[Category: Virulence]]
[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:40:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:09:15 2008''

Revision as of 20:09, 27 July 2008

Image:2oug.png

Template:STRUCTURE 2oug

Crystal structure of the RfaH transcription factor at 2.1A resolution

Template:ABSTRACT PUBMED 17434131

About this Structure

2OUG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for converting a general transcription factor into an operon-specific virulence regulator., Belogurov GA, Vassylyeva MN, Svetlov V, Klyuyev S, Grishin NV, Vassylyev DG, Artsimovitch I, Mol Cell. 2007 Apr 13;26(1):117-29. PMID:17434131

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