2oul

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oul.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2oul.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oul| PDB=2oul | SCENE= }}
{{STRUCTURE_2oul| PDB=2oul | SCENE= }}
-
'''The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family'''
+
===The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family===
-
==Overview==
+
<!--
-
Protein inhibitors of proteolytic enzymes regulate proteolysis and prevent the pathological effects of excess endogenous or exogenous proteases. Cysteine proteases are a large family of enzymes found throughout the plant and animal kingdoms. Disturbance of the equilibrium between cysteine proteases and natural inhibitors is a key event in the pathogenesis of cancer, rheumatoid arthritis, osteoporosis, and emphysema. A family (I42) of cysteine protease inhibitors (http://merops.sanger.ac.uk) was discovered in protozoan parasites and recently found widely distributed in prokaryotes and eukaryotes. We report the 2.2 A crystal structure of the signature member of the I42 family, chagasin, in complex with a cysteine protease. Chagasin has a unique variant of the immunoglobulin fold with homology to human CD8alpha. Interactions of chagasin with a target protease are reminiscent of the cystatin family inhibitors. Protein inhibitors of cysteine proteases may have evolved more than once on nonhomologous scaffolds.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17502099}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17502099 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17502099}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Macromolecular interaction]]
[[Category: Macromolecular interaction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:41:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:00:51 2008''

Revision as of 09:00, 29 July 2008

Image:2oul.png

Template:STRUCTURE 2oul

The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family

Template:ABSTRACT PUBMED 17502099

About this Structure

2OUL is a Protein complex structure of sequences from Plasmodium falciparum and Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family., Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH, Structure. 2007 May;15(5):535-43. PMID:17502099

Page seeded by OCA on Tue Jul 29 12:00:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oul"
Personal tools