2oum

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{{STRUCTURE_2oum| PDB=2oum | SCENE= }}
{{STRUCTURE_2oum| PDB=2oum | SCENE= }}
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'''The first domain of L1 from Thermus thermophilus'''
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===The first domain of L1 from Thermus thermophilus===
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==Overview==
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Ribosomal protein L1 has a dual function as a ribosomal protein binding 23S rRNA and as a translational repressor binding its mRNA. L1 is a two-domain protein with N- and C-termini located in domain I. Earlier it was shown that L1 interacts with the same targets on both rRNA and mRNA mainly through domain I. We have suggested that domain I is necessary and sufficient for specific RNA-binding by L1. To test this hypothesis, a truncation mutant of L1 from Thermus thermophilus, representing domain I, was constructed by deletion of the central part of the L1 sequence, which corresponds to domain II. It was shown that the isolated domain I forms stable complexes with specific fragments of both rRNA and mRNA. The crystal structure of the isolated domain I was determined and compared with the structure of this domain within the intact protein L1. This comparison revealed a close similarity of both structures. Our results confirm our suggestion that in protein L1 its domain I alone is sufficient for specific RNA binding, whereas domain II stabilizes the L1-rRNA complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 17962298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17962298}}
==About this Structure==
==About this Structure==
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[[Category: Ribosomal protein l1]]
[[Category: Ribosomal protein l1]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:41:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:05:04 2008''

Revision as of 11:05, 28 July 2008

Image:2oum.png

Template:STRUCTURE 2oum

The first domain of L1 from Thermus thermophilus

Template:ABSTRACT PUBMED 17962298

About this Structure

2OUM is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Domain I of ribosomal protein L1 is sufficient for specific RNA binding., Tishchenko S, Nikonova E, Kljashtorny V, Kostareva O, Nevskaya N, Piendl W, Davydova N, Streltsov V, Garber M, Nikonov S, Nucleic Acids Res. 2007;35(21):7389-95. Epub 2007 Oct 25. PMID:17962298

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